Can You Overdose on Tramadol? Risk & Treatment
Written by The Recovery Village Indianapolis
& Medically Reviewed by Dr. Kevin Wandler, MD
Medically Reviewed
Last updated: 11/28/2024
Tramadol is considered a weaker opioid, but overdose is still a serious risk. Factors like individual tolerance and genetics significantly impact a person’s likelihood of experiencing a tramadol overdose.
Key Takeaways:
- Despite being a milder opioid, tramadol can still lead to overdose.
- Tramadol overdose symptoms mirror those of other opioids but may also involve seizures.
- Tolerance and genetics both play a role in how much tramadol can lead to an overdose.
Tramadol Overdose Risks
In 2019, over 14,000 Americans died from opioid overdoses, including cases involving tramadol. While tramadol is less potent than drugs like oxycodone, it can still be dangerous, especially if taken improperly.
Always follow your doctor’s dosage instructions and be aware of overdose symptoms. In case of an overdose, immediate medical attention is critical. Call 911 or contact the National Poison Control Center at 1-800-222-1222 for guidance.
Can You Overdose on Tramadol?
Yes, tramadol overdose is possible. As a Schedule IV controlled substance, tramadol carries a risk of misuse and overdose similar to other prescription opioids.
Many people mistakenly underestimate tramadol, believing it to be safer than stronger opioids. However, tramadol affects the brain’s opioid receptors and can be just as dangerous, particularly in high doses or when combined with other substances.
Approximately 4% of people prescribed tramadol misuse it, often seeking a euphoric “high.”
Tramadol High
A tramadol high occurs when the drug is taken in excessive amounts or combined with other depressants like alcohol or muscle relaxants. People seeking a high may misuse tramadol by chewing, snorting, injecting, or smoking it rather than taking it orally as prescribed.
Safe Dosage and Overdose Risk
Doctors typically recommend:
- 50 mg of short-acting tramadol every six hours as needed.
- 100 mg of long-acting tramadol daily for new users.
Maximum doses:
- 300 mg per day for short-acting tramadol.
- 400 mg per day for long-acting tramadol.
There is no universal overdose threshold, as it varies based on tolerance and genetics. For example, someone used to taking 50 mg might overdose on a sudden increase to 400 mg.
Additionally, some people metabolize tramadol more quickly due to genetic variations in the enzyme CYP2D6, making the drug more potent in their system and increasing overdose risk.
Symptoms of a Tramadol Overdose
Tramadol overdose symptoms include:
- Respiratory depression or difficulty breathing
- Weakness, lethargy, or unconsciousness
- Cold, clammy, or discolored skin
- Dizziness, pinpoint pupils, and irregular heartbeat
- Nausea, vomiting, and muscle rigidity
- Seizures (a unique risk with tramadol compared to other opioids)
Recognizing these symptoms early can save lives. Oxygen deprivation during an overdose can lead to permanent brain damage.
Where Is Tramadol Found?
Tramadol is available both as a generic and under brand names like:
- ConZip
- Qdolo
- Ultram
It is also sold in combination with acetaminophen under the brand Ultracet.
Tramadol Overdose Treatment
If you suspect someone is overdosing on tramadol:
- Administer naloxone (Narcan) if available.
- Call 911 immediately.
In case of seizures, follow these first-aid steps:
- Gently lay the person on the floor.
- Turn them on their side to help with breathing.
- Clear nearby objects to prevent injury.
- Place a soft object under their head and remove glasses or restrictive clothing.
Seeking Help for Tramadol Addiction
Opioid addiction doesn’t have to define your future. Professional treatment can offer a path to recovery. The Recovery Village Indianapolis provides comprehensive care for individuals struggling with opioid addiction. Call today to take the first step toward recovery.
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